Download fulltext pdf download fulltext pdf download fulltext pdf. Analysis of indole alkaloids from rhazya stricta hairy. Saifine and nmethylleuconolam, new indole alkaloids from rhazya stricta. However, in most cases the biological activity of these compounds has not been studied. Yemen, saudi arabia, oman, persian gulf sheikdoms, iraq, iran, afghanistan, pakistan, india, western himalayas. Apocynaceae is an important medicinal plant that is widely distributed in the middle east and indian subcontinent.
Pdf seed oil from harmal rhazya stricta decne grown in. Phytochemical and taxonomic evaluation of rhazya stricta in saudi. This study was focused on biotechnological production tools of r. Rhazyaminine from rhazya stricta inhibits metastasis and induces.
Obaid 1, sreedhara voleti 2, roop singh bora3,4, nahid h. The present study was conducted to evaluate the allelopathic potential of two invasive plants namely rhazya stricta and artemisia monosperma on the growth of zea mays agricultural plant and lasiurus scindicus range plant inoculated with. Pdf rhazya stricta decne is an important medicinal species used in. Similar results were reported by alfarraj and alwabel 2009. Seed oil from harmal rhazya stricta decne grown in riyadh saudi arabia. Identify and characterize new compounds from rs, which inhibit genes involved in the survival, invasion, selfrenewal, and metastatic processes of cancer cells. The present study was planned to investigate the antitumor efficacy of teucrium oliverianum and rhazya stricta in chemicallyinduced hepatocellular carcinoma hcc in rats. Pdf rhazya stricta is a small glabrous shrub, widely distributed throughout western asia from yemen to arabia, to the north west. This study focused on the composition of alkaloids obtained from transformed hairy root cultures of r. Chemical investigations of roots and leaves of rhazya stricta have resulted in the isolation of the new indole alkaloids, 16r19,20eisositsirikine acetate. Effects of crude extracts from medicinal herbs rhazya. Generation of oxygen free radicals in kidney cortex plays an important role in the pathogenesis of gentamicin gm nephrotoxicity, and the leaf extract of the medicinal plant rhazya stricta has been shown to have an antioxidant action in rats. Synthesis, characterization and antibacterial activity of silver nanoparticles using rhazya stricta.
Antibacterial activities of rhazya stricta leaf extracts. Rhazya stricta decne is an important medicinal species used in indigenous medicinal herbal drugs to cure. Several metals such as silver, gold, iron, titanium, zinc, magnesium and copper have been subjected to nanoformulation for a wide range of useful applications. The methanolic extract exhibited the highest total phenolic content among the extracts. In addition to generating genomic resources for this medicinally important plant, analyses of the complete plastid and mitochondrial genomes and a nuclear transcriptome from rhazya provide insights into intercompartmental.
Review history for synthesis, characterization and. Three factors namely, temperature, ph and adsorbent dose were screened to study their effect on the adsorption of phenol by r. Request pdf on jan 1, 2007, gilani sa and others published monograph on rhazya stricta find, read and cite all the research you need on researchgate. Naturally occurring cyclotryptophans and cyclotryptamines. Analysis of transcriptional response to heat stress in. Antibacterial activities of rhazya stricta leaf extracts against multidrugresistant human pathogens raziuddin khan a, mohammed n. Phytochemical and taxonomic evaluation of rhazya stricta. In vitro antifungal activity of rhazya stricta article pdf available in pakistan journal of pharmaceutical sciences 204.
Phytochemical, pharmacological and ethnobotanical studies. Saudi arabia, qatar, united arab emirates uae, iran and iraq. The prepared activated carbon was characterized by ftir and sem analysis. A novel activated carbon was prepared from rhazya stricta leaves and was successfully used as an adsorbent for phenol removal from aqueous solution. Rhazya stricta decne is an important medicinal species used in indigenous medicinal herbal drugs to cure various diseases in south asia pakistan, india and afghanistan and in the middle east e. The aim of our study is to examine the morphological and. Determination of terpenoid indole alkaloids in hairy roots. It contains a large number of terpenoid indole alkaloids tias, some of which possess interesting pharmacological properties. Phytochemistry, pharmacology and toxicity of rhazya. The study material including transgenic hairy root cultures have been developed and their potential for alkaloid production are being investigated. Rhazya stricta is a medicinally important plant native to south asia. Rhazya stricta decaisne apocynaceae is characterized by its high contents of certain indole alkaloids chatterjee et al.
Rhazya stricta is a medicinal plant that is widely used in saudi folklore medicine for treatment of various diseases. Rhazya stricta is native to arid regions in south asia and the middle east and is used extensively in folk medicine to treat a wide range of diseases. The role of alkaloids isolated from rhazya stricta decne. In the uplcms analyses, a total of 20 tias were identified from crude extracts. Rhazya stricta is an evergreen shrub that is widely distributed across western and south asia, and like many other members of the apocynaceae produces monoterpene indole alkaloids that have anticancer properties. Sabir3 and kulvinder singh saini3,4 abstract rhazya stricta is a unique medicinal plant source for many indole alkaloids, nonalkaloids, flavonoids, triterpenes and.
Rhazya stricta is a unique medicinal plant source for many indole alkaloids, nonalkaloids, flavonoids, triterpenes and other unknown molecules with. Pdf the indolealkaloid fraction of rhazya stricta improves key. Phytochemical, pharmacological and toxicological properties of the medicinal plant rhazya stricta decne. Rhazyaminine from rhazya stricta inhibits metastasis and. Ibhrahim department of botany and microbiology, college of science, king saud university, po box22452, riyadh 11495, saudi arabia. Biotechnology of the medicinal plant rhazya stricta. Adsorption of phenol onto activated carbon from rhazya. Structure and absolute configuration of strictamine and.
Synthesis, characterization and antibacterial activity of. This species is adapted to very harsh desert conditions making it an excellent system for studying tolerance to high temperatures and salinity. The cytotoxic effects of these fractions on human breast cancer cells mdamb231 and mcf7 and nontumorigenic control cells mcf10a were. However, the yields of these compounds are very low. Rhazya is a genus of plant in family apocynaceae first described as a genus in 1835. Teucrium oliverianum and rhazya stricta are medicinal plants used in traditional and herbal medicine for the treatment of diabetes, liver diseases and inflammatory conditions. This name is the accepted name of a species in the genus rhazya family apocynaceae the record derives from wcsp data supplied on 20120323 which reports it as an accepted name record 177985 with original publication details. Apoptotic induction and antimigratory effects of rhazya. Growth and metabolic responses of rhazya stricta decne to habitat.
Rhazya stricta diceisne, a gregarious dwarf shrub which grows wild in west pakistan and is rich in alkaloids14, proved to have a leucopenic effect. Each column and vertical bar represent mean sem n 7 rats. Taxonomy of rhazya stricta decne family apocynaceae in saudi arabia is well documented. Phytochemical and pharmacological aspects of the species have been thoroughly explored. Eshvarak is a native poisonous plant in southern iran, afghanistan, pakistan, india, iraq, oman, yemen, and saudi arabia. The effect of treatment with the medicinal plant rhazya stricta decne, on monoamine oxidase mao and cholinesterase activity, and on the concentration of brain biogenic amines was studied in rats. Original article phytochemical and taxonomic evaluation of rhazya stricta in saudi arabia najat a. The nuclear genome of rhazya stricta and the evolution of alkaloid. Apocynaceae contains a large number of terpenoid indole alkaloids tias. It is native to egypt and to southwestern asia from yemen to india species. Therefore, in the present work we aimed at testing, in this species, the possible protective effect of r. Uae rhazya stricta decne extract as a corrosion inhibitor. Divergent structural evolution in rhazya stricta genome level rearrangements leading from the ancestral core eudicot, represented by vitis upper.
Desert plants have already adapted to high levels of heat stress so they make excellent systems for identifying genes involved in thermotolerance. Several types of alkaloids and a few flavonoids have been isolated and their structures and stereochemistry characterized. Pdf in vitro antifungal activity of rhazya stricta researchgate. Antioxidant properties of methanolic extracts from leaves. Rhazya stricta decne harmal, a member of the apocynaceae family, is an important medicinal species used in folkloric medicine to cure various diseases in south asia and the middle east 11, 12. The effect of treatment with the medicinal plant rhazya. Seed oil from harmal rhazya stricta decne grown in. Apocynaceae is a medicinal plant rich in terpenoid indole alkaloids tias, some of which possess important pharmacological properties. Complete sequences of organelle genomes from the medicinal. Semantic scholar extracted view of scientific name. It is widely distributed throughout western asia from yemen to arabia throughout the middle east, to the north west province of india, south asia and abundantly found in various regions of pakistan gilani et al. Rhazya stricta decsne apocynaceae family, a traditional herbal medicinal plant from western and south asia, has been shown to have multiple pharmacological effects due to the presence of over 100 alkaloids 1,2,3. Transcriptomic analysis of salt stress responsive genes in. In the present study, tocol tocopherol and tocotrienol, triacylglycerol, and fatty acid compositions, pigment content, thermal behavior, and various physicochemical properties of.
Rhazya stricta wikispecies wikispecies, free species. The rhazya stricta exhibiting tf values less than one except for zn 1. Text is available under the creative commons attributionsharealike license. Some of its alkaloids have been reported to have anticancerous properties. Efficacy of rhazya stricta leaf and seed extracts against rhyzopertha dominica and trogoderma granarium.
Establishment of a reliable, reproducible and efficient transformation. Establishment of transgenic rhazya stricta hairy roots to modulate terpenoid indole alkaloid production. It is used as a medicinal plant in traditional cultures and the seeds are a source of unsaturated oil. Rhazya stricta is an evergreen shrub that is native to extremely hot regions across western and south asia. Cheminformatics studies to analyze the therapeutic. It produces a large number of terpenoid indole alkaloids tias some of which possess important pharmacological properties. Rhazya is unique among the eight sequenced asterids in the types of events that have shaped the evolution of its mitochondrial genome. Extraction of antioxidants was carried out in different solvent systems, i. The role of alkaloids isolated from rhazya stricta decne apocynaceae family rs in targeting genes involved in cancer and metastasis remains to be elucidated. Pdf allelopathic impact of rhazya stricta dence and.
Mountain, plain and wadi diversity on growth behavior and metabolic activities of one common perennial dwarf shrub rhazya stricta. Background green synthesis of metallic nanoparticles has gained significant attention in the field of nanomedicine as an environmentfriendly and costeffective alternative in comparison with other physical and chemical methods. Climate change is predicted to be a serious threat to agriculture due to the need for crops to be able to tolerate increased heat stress. The aqueous rhazya stricta decne leaves extract was found to be a highly efficient inhibitor for mild steel in 1.
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